Original Publications

• Qi Jin, Blanca Gutierrez Diaz, Tim Pieters, Yalu Zhou, Sonali Narang, Igor Fijalkwoski, Cristina Borin, Jolien Van Laere, Monique Payton, Byoung-Kyu Cho, Cuijuan Han, Limin Sun, Valentina Serafin, George Yacu, Wouter Von Loocke, Giuseppe Basso, Giulia Veltri, Ingrid Dreveny, Issam Ben-Sahra, Young Ah Goo, Stephanie L Safgren, Yi-Chien Tsai, Beat Bornhauser, Praveen Kumar Suraneni, Alexandre Gaspar-Maia, Irawati Kandela, Pieter Van Vlierberghe, John D. Crispino, Aristotelis Tsirigos and Panagiotis Ntziachristos# (2022). Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia. Science Advances, 2022 Dec 9;8(49):eabq8437
• Cuijuan Han, Khodadadi-Jamayran A, Lorch AH, Jin Q, Serafin V, Zhu P, Politanska Y, Sun L, Gutierrez-Diaz BT, Pryzhkova MV, Abdala-Valencia H, Bartom ET, Buldini B, Basso G, Velu SE, Sarma K, Mattamana BB, Cho BK, Obeng RC, Goo YA, Jordan PW, Tsirigos A, Zhou Y, Panagiotis Ntziachristos# (2022). SF3B1 homeostasis is critical for survival and therapeutic response in T cell leukemia. Science Advances, Jan 21;8(3).
• Su H. Park, Will Fong, Jung Kim, Yongik Lee, Xiaodong Lu, Fang Wang, Lourdes T. Brea, Kristine Wadosky, Chunming Guo, Sarki A. Abdulkadir, John D. Crispino, Deyu Fang, Panagiotis Ntziachristos, Xue Li, Yong Wan, David W. Goodrich3, Jonathan C. Zhao, Jindan Yu (2021). Post-translational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer. Sciences Advances, Apr 7;7(15):eabe2261.
• Christian Marinaccio, Praveen Suraneni, Hamza Celik, Andrew Volk, Qiang Jeremy Wen, Te Ling, Marinka Bulic, Terra Lasho, Richard Koche , Christopher Famulare, Noushin Farnoud, Brady Stein, Michael Schieber, Sandeep Gurbuxani, David E. Root, Scott T. Younger, Ronald Hoffman, Naseema Gangat, Panagiotis Ntziachristos, Navdeep S. Chandel, Ross L Levine, Raajit K. Rampal, Grant A. Challen, Ayalew Tefferi, and John D. Crispino (2021). LKB1/STK11 is a tumor suppressor in the leukemic transformation of the myeloproliferative neoplasms. Cancer Discovery, Feb 12:candisc.1353.2020
• Shashank Srivastava, Umakant Sahu, Yalu Zhou, Ann K. Hogan, Kizhakke Mattada Sathyan, Justin Bodner, Jiehuan Huang, Kelvin A. Wong, Natalia Khalatyan, Jeffrey N. Savas, Panagiotis Ntziachristos, Issam Ben-Sahra, and Daniel R. Foltz (2021). The NOTCH1-driven UBR7 Stimulates Nucleotide Biosynthesis to Promote T-Cell Acute Lymphoblastic Leukemia. Sciences Advances, Jan 27;7(5):eabc9781
• Celestia Fang*, Zhenjia Wang*, Cuijuan Han, Stephanie L. Safgren, Kathryn A. Helmin, Emmalee R. Adelman, Valentina Serafin, Giuseppe Basso, Kyle P. Eagen, Alexandre Gaspar-Maia, Maria E. Figueroa, Benjamin D. Singer, Aakrosh Ratan, Panagiotis Ntziachristos#,$, Chongzhi Zang#,$ (2020). Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation. Genome Biology, Sep 15;21(1):247
• Yalu Zhou, Cuijuan Han, Eric Wang, Adam H. Lorch, Valentina Serafin, Byoung-Kyu Cho, Blanca T. Gutierrez Diaz, Julien Calvo, Celestia Fang, Alireza Khodadadi-Jamayran, Tommaso Tabaglio, Christian Marier, Anna Kuchmiy, Limin Sun, George Yacu, Szymon K. Filip, Qi Jin, Yoh-hei Takahashi, David R. Amici, Emily J. Rendleman, Radhika Rawat, Silvia Bresolin, Maddalena Paganin, Cheng Zhang, Hu Li, Irawati Kandela, Yuliya Politanska, Hiam Abdala-Valencia, Marc L. Mendillo, Ping Zhu, Bruno Palhais, Pieter Van Vlierberghe, Tom Taghon, Iannis Aifantis, Young Ah Goo, Ernesto Guccione, Adriana Heguy, Aristotelis Tsirigos, Keng Boon Wee, Rama K. Mishra, Francoise Pflumio, Benedetta Accordi, Giuseppe Basso, and Panagiotis Ntziachristos# (2020). Posttranslational regulation of the exon skipping machinery controls aberrant splicing in leukemia. Cancer Discovery, Sep;10(9):1388-1409
• Andreas Kloetgen*, Palaniraja Thandapani*, Panagiotis Ntziachristos*, Yohana Ghebrechristos, Sofia Nomikou, Charalampos Lazaris, Xufeng Chen, Hai Hu, Sofia Bakogianni, Jingjing Wang, Yi Fu, Francesco Boccalatte, Hua Zhong, Elisabeth Paietta, Thomas Trimarchi, Yixing Zhu, Pieter van Vlierberghe, Giorgio G Inghirami, Timothee Lionnet, Iannis Aifantis and Aristotelis Tsirigos (2020). Dynamic 3D chromosomal landscapes in acute leukemia, Nature Genetics, Apr; 52:388–400.
• Qi Jin*, Carlos A. Martinez*, Kelly M. Arcipowski*, Yixing Zhu, Blanca Teresa Gutierrez Diaz, Kenneth K. Wang, Megan R. Johnson, Andrew G. Volk, Feng Wang, Jian Wu, Hui Wang, Ivan Sokirniy, Paul M. Thomas, Young Ah Goo, Nebiyu A. Abshiru, Nobuko Hijiya, Sofie Peirs, Niels Vandamme, Geert Berx, Steven Goosens, Stacy A. Marshall, Emily J. Rendleman, Yoh-hei Takahashi, Lu Wang, Elizabeth T. Bartom, Clayton K. Collings, Pieter Van Vlierberghe, Alexandros Strikoudis, Stephen Kelly, Beatrix Ueberheide, Christine Mantis, Irawati Kandela, Jean-Pierre Bourquin, Beat Bornhauser, Valentina Serafin, Silvia Bresolin, Maddalena Paganin, Benedetta Accordi, Giuseppe Basso, Neil L. Kelleher, Joseph Weinstock, Suresh Kumar, John D. Crispino, Ali Shilatifard, and Panagiotis Ntziachristos# (2019). USP7 cooperates with NOTCH1 to drive the oncogenic transcriptional program in T cell leukemia. Clinical Cancer Research, Jan 1;25(1):222-239
• Lu Wang, Zibo Zhao, Patrick A. Ozark, Damiano Fantini, Stacy A. Marshall, Emily J. Rendleman, Kira A. Cozzolino, Nundia Louis, Xingyao He, Marc A. Morgan, Yoh-hei Takahashi, Clayton Collings, Edwin R. Smith, Panagiotis Ntziachristos, Jeffrey N. Savas, Lihua Zou, Rintaro Hashizume, Joshua  J. Meeks, Ali Shilatifard (2018). Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy. Nat Med. 2018 May 21
• Yixiao Gong, Charalambos Lazaris, Theodore Sakellaropoulos, Aurelie Lozano, Prabhajian Kambadur, Panagiotis Ntziachristos, Ioannis Aifantis, Aristotelis Tsirigos (2018). Stratification of TAD boundaries reveals preferential insulation of super-enhancers by strong boundaries. Nat Commun., 2018 Feb 7;9(1):542
• Alexandros Strikoudis, Charalampos Lazaris, Panagiotis Ntziachristos, Aristotelis Tsirigos, and Iannis Aifantis (2017). Opposing functions of H2BK120 ubiquitylation and H3K79 methylation in the regulation of pluripotency by the Paf1 complex. Cell Cycle, 2017 Mar 8:0
• Charalampos Lazaris, Stephen Kelly, Panagiotis Ntziachristos, Iannis Aifantis and Aristotelis Tsirigos (2017). HiC-bench: comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking. BMC Genomics, 5;18(1):22
• Alexandros Strikoudis, Charalampos Lazaris, Thomas Trimarchi, Antonio Neto, Yan Yang, Panagiotis Ntziachristos, Scott Rothbart, Shannon Buckley, Igor Dolgalev, Matthias Stadtfeld, Brian Strahl, Brian Dynlacht, Aristotelis Tsirigos, and Iannis Aifantis (2016). Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a. Nature Cell Biology, 18(11):1127-1138
• Jinghui Zhang, Kelly McCastlain, Gang Wu, Yongjin Li, Lei Wei, Ilaria Iacobucci, Yu Liu, Chunxu Qu, Beisi Xu, Ji Wen, Michael Edmonson, Debbie Payne-Turner, Hiroki Yoshihara, Yunchao Chang, Michelle L. Churchman, Esmé Waanders, Panagiotis Ntziachristos, Sofia Bakogianni, Jingjing Wang, Iannis Aifantis, Kathryn G. Roberts, Jing Ma, Guangchun Song, John Easton, Heather L. Mulder, Xiang Chen, Scott Newman, Xiaotu Ma, Michael Rusch, Pankaj Gupta, Kristy Boggs, Bhavin Vadodaria, James Dalton, Yanling Liu, Marcus L Valentine, Li Ding, Charles Lu, Robert S. Fulton, Lucinda Fulton, Yashodan Tabib, Kerri Ochoa, Meenakshi Devidas, Deqing Pei, Cheng Cheng, Jun Yang, William E. Evans, Mary V. Relling, Ching-Hon Pui, Sima Jeha, Richard C. Harvey, I-Ming L Chen, Cheryl L. Willman, Guido Marcucci, Clara D. Bloomfield, Jessica Kohlschmidt, Krzysztof Mrozek, Elisabeth Paietta, Martin S. Tallman, Wendy Stock, Peter M. Voorhees, Janis Racevskis, Jacob M. Rowe, Selina Luger, Steven M. Kornblau, Sheila A Shurtleff, Susana C. Raimondi, Elaine R. Mardis, Richard K. Wilson, Stephen P Hunger, Mignon L. Loh, James R. Downing, and Charles G. Mullighan for the St Jude Children’s Research Hospital – Washington University Pediatric Cancer Genome Project. (2016). Simultaneous deregulation of DUX4 and ERG in acute lymphoblastic leukemia. Nature Genetics, 48(12):1481-1489
• Konstantinos Drosatos, Nina M. Pollak, Christine J. Pol, Panagiotis Ntziachristos, Florian Willecke, Mesele-Christina Valenti, Chad M. Trent, Yunying Hu, Shaodong Guo, Iannis Aifantis, Ira J. Goldberg (2016). Cardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac Function. Circ. Res., 118(2):241-53
• Raffaella Di Micco, Barbara Fontanals-Cirera, Vivian Low, Panagiotis Ntziachristos, Stephanie K Yuen, Claudia D. Lovell, Igor Dolgalev, Yoshiya Yonekubo, Guantao Zhang, Elena Rusinova, Guillermo Gerona-Navarro, Marta Cañamero, Michael Ohlmeyer, Iannis Aifantis, Ming-Ming Zhou, Aristotelis Tsirigos and Eva Hernando (2014). Control of embryonic stem cell identity by BRD4-dependent transcriptional elongation of super-enhancer associated pluripotency genes. Cell Reports, 9, 234-247
• Panagiotis Ntziachristos*, Aristotelis Tsirigos*, G. Grant Welstead, Thomas Trimarchi, Sofia Bakogianni, Luyao Xu, Evangelia Loizou, Linda Holmfeldt, Alexandros Strikoudis, Bryan King, Jasper Mullenders, Jared Becksfort, Jelena Nedjic, Elisabeth Paietta, Martin S. Tallman, Jacob M. Rowe, Giovanni Tonon, Takashi Satoh, Laurens Kruidenier, Rab Prinjha, Shizuo Akira, Pieter Van Vlierberghe, Adolfo A. Ferrando, Rudolf Jaenisch, Charles G. Mullighan and Iannis Aifantis (2014). Contrasting roles for histone 3 lysine 27 demethylases in acute lymphoblastic leukemia. Nature, 514, 513-517
• Thomas Trimarchi, Erhan Bilal, Panagiotis Ntziachristos, Giulia Fabbri, Ricardo Dalla-Favera, Aristotelis Tsirigos and Iannis Aifantis (2014). Genome-wide mapping and characterization of Notch-regulated long noncoding RNAs in acute leukemia. Cell, 158, 593–606.
• Julie Chaumeil, Mariann Micsinai, Panagiotis Ntziachristos, David B. Roth, Iannis Aifantis, Yuval Kluger, Ludovic Deriano and Jane A. Skok (2013). The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavage. Nature Communications, 4:2231
• Bryan King, Thomas Trimarchi, Linsey Reavie, Luyao Xu, Jasper Mullenders, Panagiotis Ntziachristos, Beatriz Aranda-Orgilles, Arianne Perez-Garcia, Junwei Shi, Christopher Vakoc, Peter Sandy, Steven S. Shen, Adolfo A. Ferrando and Iannis Aifantis (2013). The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability. Cell, 153(7):1552-66
• Camille Lobry, Panagiotis Ntziachristos, Delphine Ndiaye-Lobry, Philmo Oh, Luisa Cimmino, Nan Zhu, Elisa Araldi, Wenhuo Hu, Jacquelyn Freund, Omar Abdel-Wahab, Sherif Ibrahim, Dimitris Skokos, Scott A. Armstrong, Ross L. Levine, Christopher Y. Park and Iannis Aifantis (2013). Notch Pathway Activation Targets AML Initiating Cell Homeostasis and Differentiation. Journal of Experimental Medicine, 210(2):301-19
• Julie Chaumeil, Mariann Micsinai, Panagiotis Ntziachristos, Ludovic Deriano, Joy M.-H. Wang, Yanhong Ji, Elphege P. Nora, Yuval Kluger, Iannis Aifantis, David G. Schatz and Jane A. Skok (2013). Higher-order looping and nuclear organization of antigen receptor loci facilitates targeted RAG cleavage and regulated rearrangement in recombination centers. Cell Reports, 3(2):359-70
• Panagiotis Ntziachristos*, Aristotelis Tsirigos*, Pieter Van Vlierberghe, Jelena Nedjic, Thomas Trimarchi, Maria Sol Flaherty, Dolors Ferres-Marco, Vanina da Ros, Zuojian Tang, Jasmin Siegle, Patrik Asp, Michael Hadler, Isaura Rigo, Kim De Keersmacker, Jay Patel, Tien Huynh, Filippo Utro, Sandrine Poglio, Jeremy B. Samon, Elisabeth Paietta, Janis Racevskis, Jacob M. Rowe, Raul Rabadan, Ross L. Levine, Stuart Brown, Francoise Pflumio, Adolfo Ferrando and Iannis Aifantis (2012). Genetic Inactivation of the polycomb repressive complex 2 in T-cell acute lymphoblastic leukemia. Nature Medicine, 18(2):298-301

 
         Reviews and Previews

• Jonas De Kesel, Igor Fijalkowski, Justin Taylor, Panagiotis Ntziachristos# (2022). Splicing dysregulation in human hematologic malignancies: beyond splicing mutations. Trends in Immunology, Aug;43(8):674-686.
• Celestia Fang, Sridhar Rao, John D. Crispino# and Panagiotis Ntziachristos# (2020). Determinants and role of chromatin organization in acute leukemia. Leukemia. Oct;34(10):2561-2575
• Blanca Gutierrez, Wei Gu and Panagiotis Ntziachristos# (2020). Deubiquitinases: Pro-oncogenic Activity and Therapeutic Targeting in Blood Malignancies. Trends in Immunology, Apr;41(4):327-340
• Panagiotis Ntziachristos# (2019). PHF6: it is written in the stem cells. Blood. Jun 6;133(23):2461-2462
• Radhika Rawat, Daniel Starczynowski and Panagiotis Ntziachristos# (2019). Nuclear deubiquitination in the spotlight: the multifaceted nature of USP7 biology in disease. Current Opinions in Cell Biology, Mar 18;58:85-94

• Panagiotis Ntziachristos#, Omar Abdel-Wahab# and Ioannis Aifantis# (2016). Emerging concepts of epigenetic dysregulation in hematological malignancies. Nature Immunology, 17(9):1016-24
• Kelly Marie Arcipowski, Carlos Alberto Martinez and Panagiotis Ntziachristos# (2016). Histone demethylases in physiology and cancer: A tale of two enzymes, JMJD3 and UTX. Current Opinions in Genetics & Development, 36: 59–67
• Panagiotis Ntziachristos, Jing Shan Lim, Julien Sage and Iannis Aifantis (2014). From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling. Cancer Cell, 25: 318-334
• Thomas Trimarchi, Panagiotis Ntziachristos and Iannis Aifantis (2013). A new player SETs in myeloid malignancy. Nature Genetics, 45(8):846-7
• Panagiotis Ntziachristos*, Jasper Mullenders*, Thomas Trimarchi, and Iannis Aifantis (2013). The Epigenetic Landscape of Acute Leukemias. Advances in Immunology, 117:1-38
• Bryan King, Panagiotis Ntziachristos and Iannis Aifantis (2012). High-jacking T cell differentiation: New insights in TLX function in T-ALL. Cancer Cell, 21(4) :453 – 455
• *, $ equal contribution
• # corresponding author